New treatments and new assessment instruments for hidradenitis suppurativa

van Straalen, K. R., Ingram, J. R. ORCID: https://orcid.org/0000-0002-5257-1142, Augustin, M. and Zouboulis, C. C. 2022. New treatments and new assessment instruments for hidradenitis suppurativa. Experimental Dermatology 31 (s1) , pp. 33-39. 10.1111/exd.14609

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Abstract

Research interest in Hidradenitis Suppurativa (HS) has grown exponentially over the past decades. Several groups have worked to develop novel scores that address the drawbacks of existing investigator assessed and patient reported outcome measures currently used in HS trials, clinical practice and research. In clinical trial settings, the drawbacks of the HiSCR have become apparent; mainly it’s lack of a dynamic measurement of draining tunnels. The newly developed (dichotomous) IHS4 and HASI-R are backed up by adequate validation data and are good contenders to become the new primary outcome measure in HS clinical trials. Patient reported outcomes, as well as physician reported measures, are being developed by the HIdradenitis SuppuraTiva cORe outcomes set International Collaboration (HISTORIC). For example, the Hidradenitis Suppurativa Quality of Life (HiSQOL) score is a validated measure of HS-specific quality of life and is already being used in many HS trials. Magnitude of pain measurement via a 0-10 numerical rating scale is well-established, however consensus is still required to ensure consistent administration and interpretation of the instrument. A longitudinal measurement over multiple days rather than at one time point, such as for example the Pain Index could provide increased reliability and reduced recall bias.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Wiley
ISSN:	0906-6705
Date of First Compliant Deposit:	21 May 2022
Date of Acceptance:	18 May 2022
Last Modified:	03 May 2023 10:32
URI:	https://orca.cardiff.ac.uk/id/eprint/149923

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