Recruitment of frontal-sensory circuits during visual discrimination

Broom, Eluned, Imbriotis, Vivian, Sengpiel, Frank ORCID: https://orcid.org/0000-0002-7060-1851, Connelly, William M and Ranson, Adam ORCID: https://orcid.org/0000-0002-4804-0832 2022. Recruitment of frontal-sensory circuits during visual discrimination. Cell Reports 39 (10) , 110932. 10.1016/j.celrep.2022.110932

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Abstract

A long-range circuit linking the medial frontal cortex to the primary visual cortex (V1) has been proposed to mediate visual selective attention in mice during visually guided behavior. Here, we use in vivo two-photon functional imaging to measure the endogenous activity of axons of A24b/M2 neurons from this region projecting to layer 1 of V1 (A24b/M2-V1axons) in mice either passively viewing stimuli or performing a go/no-go visually guided task. We observe that while A24b/M2-V1axons are recruited under these conditions, this is not linked to enhancement of neural or behavioral measures of sensory coding. Instead, A24b/M2-V1axon activity is associated with licking behavior, modulated by reward, and biased toward the sensory cortical hemisphere representing the stimulus currently being discriminated.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
Additional Information:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Publisher:	Cell Press
ISSN:	2211-1247
Funders:	BBSRC, Wellcome Trust
Date of First Compliant Deposit:	30 May 2022
Date of Acceptance:	18 May 2022
Last Modified:	10 Feb 2024 02:17
URI:	https://orca.cardiff.ac.uk/id/eprint/150115

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