Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.

Volta, M, Cataldi, S, Beccano-Kelly, D ORCID: https://orcid.org/0000-0003-3592-8354, Munsie, L, Tatarnikov, I, Chou, P, Bergeron, S, Mitchell, E, Lim, R, Khinda, J, Lloret, A, Bennett, C F, Paradiso, C, Morari, M, Farrer, M J and Milnerwood, A J 2015. Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release. Parkinsonism & Related Disorders 21 (10) , pp. 1156-1163. 10.1016/j.parkreldis.2015.07.025

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Abstract

Germline silencing of the PD-related protein LRRK2 does not alter glutamate or dopamine release in adult mice, but some exploratory abnormalities have been reported with ageing. Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopamine levels, with the latter also observed in G2019S mutant mice. Comparative cognitive and motor behavioral testing of LRRK2 KO, overexpressor and mutant overexpressor mice has not previously been reported.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	1353-8020
Last Modified:	10 Nov 2022 11:20
URI:	https://orca.cardiff.ac.uk/id/eprint/150134

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