Volta, M, Cataldi, S, Beccano-Kelly, D ![]() |
Official URL: http://europepmc.org/abstract/med/26282470
Abstract
Germline silencing of the PD-related protein LRRK2 does not alter glutamate or dopamine release in adult mice, but some exploratory abnormalities have been reported with ageing. Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopamine levels, with the latter also observed in G2019S mutant mice. Comparative cognitive and motor behavioral testing of LRRK2 KO, overexpressor and mutant overexpressor mice has not previously been reported.
Item Type: | Article |
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Date Type: | Published Online |
Status: | Published |
Schools: | Medicine |
Publisher: | Elsevier |
ISSN: | 1353-8020 |
Last Modified: | 10 Nov 2022 11:20 |
URI: | https://orca.cardiff.ac.uk/id/eprint/150134 |
Citation Data
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