Synthesis and structure determination of 2-cyano-3-(1-phenyl-3-(thiophen-2-yl)-1 H -pyrazol-4-yl)acrylamide

Kariuki, Benson M. ORCID: https://orcid.org/0000-0002-8658-3897, Abdel-Wahab, Bakr F., Mohamed, Hanan A. and El-Hiti, Gamal A. ORCID: https://orcid.org/0000-0001-6675-3126 2022. Synthesis and structure determination of 2-cyano-3-(1-phenyl-3-(thiophen-2-yl)-1 H -pyrazol-4-yl)acrylamide. Molbank 2022 (2) , eM1372. 10.3390/m1372

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Abstract

2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide (3) was synthesized in 90% yield from condensation of equimolar equivalents of 1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde (1) and 2-cyanoacetamide (2) in boiling ethanol under basic condition for 45 min. The structure of 3 was determined using NMR spectroscopy and single crystal X-ray diffraction.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Chemistry
Additional Information:	License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/
Publisher:	MDPI
Date of First Compliant Deposit:	1 June 2022
Date of Acceptance:	28 May 2022
Last Modified:	15 May 2023 21:35
URI:	https://orca.cardiff.ac.uk/id/eprint/150194

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