Transparency in non-technical summaries to sustain the 3Rs in respiratory diseases research

Bonassera, Martina, Clews, Esther and Berube, Kelly ORCID: https://orcid.org/0000-0002-7471-7229 2022. Transparency in non-technical summaries to sustain the 3Rs in respiratory diseases research. Alternatives to Laboratory Animals 50 (5) , pp. 349-364. 10.1177/0261192922112107

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Abstract

Non-Technical Project Summaries (NTS) are legal documents that were first introduced by the Directive 2010/63/EU to enhance transparency within scientific animal experimentation. Researchers intending to conduct biological research on animal models must fulfil the NTS requirements by outlining their proposed use of animals and how they plan to implement the Three Rs (replacement, reduction and refinement of animal use) in their experiments. This study outlines a novel systematic analysis approach that enables the assessment of NTS transparency based on the accuracy of reporting of certain Three Rs-specific information. This potentially customisable strategy could help toward the development of practical guidelines for use by Animal Welfare and Ethical Review Bodies (AWERBs) in establishments conducting animal research, in the process of scrutinising NTS during their pre-submission review of proposed licence applications. This could help to identify gaps in reporting of Three Rs-specific information relating to the planned animal experiments, which represents a remarkable step toward achieving greater openness in scientific communication. This study supports the concept that NTS transparency can promote the implementation of non-animal alternatives in fields where this is currently lacking, such as respiratory disease research. Although NTS were originally conceived as informative documents for a lay audience, we can conclude that data in NTS can be successfully used as a basis for systematic analysis. By reviewing the NTS, the experimental limitations of the currently available replacement strategies can also be highlighted, potentially pinpointing where there is a need for future method development.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Fund for the Replacement of Animals in Medical Experiments (FRAME)
ISSN:	0261-1929
Date of First Compliant Deposit:	9 June 2022
Date of Acceptance:	20 March 2022
Last Modified:	21 Nov 2023 10:28
URI:	https://orca.cardiff.ac.uk/id/eprint/150298

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