Place cells in the claustrum remap under NMDA receptor control

Rizzello, Emanuela, Martin, Seán K., Rouine, Jennifer, Callaghan, Charlotte, Mathiasen, Mathias L. and O'Mara, Shane M. 2022. Place cells in the claustrum remap under NMDA receptor control. European Journal of Neuroscience 56 (2) , pp. 3825-3838. 10.1111/ejn.15726

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Abstract

Place cells are cells that exhibit location‐dependent responses; they have mostly been studied in the hippocampus. Place cells have also been reported in the rat claustrum, an underexplored paracortical region with extensive corto‐cortical connectivity. It has been hypothesised that claustral neuronal responses are anchored to cortical visual inputs. We show rat claustral place cells remap when visual inputs are eliminated from the environment, and that this remapping is NMDA‐receptor‐dependent. Eliminating visual input decreases claustral delta‐band oscillatory activity, increases theta‐band oscillatory activity, and increases simultaneously recorded visual cortical activity. We conclude that, like the hippocampus, claustral place field remapping might be mediated by NMDA receptor activity, and is modulated by visual cortical inputs.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/
Publisher:	Wiley
ISSN:	0953-816X
Date of First Compliant Deposit:	20 June 2022
Date of Acceptance:	18 May 2022
Last Modified:	15 May 2023 15:27
URI:	https://orca.cardiff.ac.uk/id/eprint/150608

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