In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene.

Pravica, V., Asderakis, A. ORCID: https://orcid.org/0000-0001-6859-2020, Perrey, C., Hajeer, A., Sinnott, P.J. and Hutchinson, I.V. 1999. In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene. European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 26 (1) , pp. 1-3. 10.1046/j.1365-2370.1999.00122.x

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Abstract

The DNA sequence of the human IFN-γ gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-γ (IFN-γ) production. In vitro production of IFN-γ showed a significant correlation with the presence of allele #2.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Last Modified:	19 Jan 2023 13:45
URI:	https://orca.cardiff.ac.uk/id/eprint/150694

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