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The spatiotemporal dynamics of cerebral autoregulation in functional magnetic resonance imaging

Whittaker, Joseph R., Steventon, Jessica J., Venzi, Marcello and Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X 2022. The spatiotemporal dynamics of cerebral autoregulation in functional magnetic resonance imaging. Frontiers in Neuroscience 16 , 795683. 10.3389/fnins.2022.795683

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Abstract

The thigh-cuff release (TCR) maneuver is a physiological challenge that is widely used to assess dynamic cerebral autoregulation (dCA). It is often applied in conjunction with Transcranial Doppler ultrasound (TCD), which provides temporal information of the global flow response in the brain. This established method can only yield very limited insights into the regional variability of dCA, whereas functional MRI (fMRI) has the ability to reveal the spatial distribution of flow responses in the brain with high spatial resolution. The aim of this study was to use whole-brain blood-oxygenation-level-dependent (BOLD) fMRI to characterize the spatiotemporal dynamics of the flow response to the TCR challenge, and thus pave the way toward mapping dCA in the brain. We used a data driven approach to derive a novel basis set that was then used to provide a voxel-wise estimate of the TCR associated haemodynamic response function (HRFTCR). We found that the HRFTCR evolves with a specific spatiotemporal pattern, with gray and white matter showing an asynchronous response, which likely reflects the anatomical structure of cerebral blood supply. Thus, we propose that TCR challenge fMRI is a promising method for mapping spatial variability in dCA, which will likely prove to be clinically advantageous.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Physics and Astronomy
Additional Information: License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/
Publisher: Frontiers Media
ISSN: 1662-4548
Date of First Compliant Deposit: 25 July 2022
Date of Acceptance: 20 June 2022
Last Modified: 10 Nov 2022 11:40
URI: https://orca.cardiff.ac.uk/id/eprint/151444

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