Seastram, Alex C., Hareram, Mishra Deepak, Knight, Thomas M. B. and Morrill, Louis C.  ORCID: https://orcid.org/0000-0002-6453-7531
2022.
Electrochemical alkene azidocyanation via 1,4-nitrile migration.
Chemical Communications
58
, pp. 8658-8661.
10.1039/D2CC02958H
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Official URL: http://dx.doi.org/10.1039/D2CC02958H
Abstract
An electrochemical method for the azidocyanation of alkenes via 1,4-nitrile migration has been developed. This organic oxidant free method is applicable across various alkene containing cyanohydrins, and provides access to a broad range of synthetically useful 1,2-azidonitriles (28 examples). This methodology was extended to an electrochemical alkene sulfonylcyanation procedure, as well as to access a trifunctionalized hexanenitrile from a malononitrile starting material. The orthogonal derivatization of the products was also demonstrated through chemoselective transformations.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Chemistry Research Institutes & Centres > Cardiff Catalysis Institute (CCI) |
| Additional Information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| Funders: | EPSRC |
| Date of First Compliant Deposit: | 26 July 2022 |
| Date of Acceptance: | 6 July 2022 |
| Last Modified: | 07 Jul 2023 00:45 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/151466 |
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