Seastram, Alex C., Hareram, Mishra Deepak, Knight, Thomas M. B. and Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 2022. Electrochemical alkene azidocyanation via 1,4-nitrile migration. Chemical Communications 58 , pp. 8658-8661. 10.1039/D2CC02958H |
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Official URL: http://dx.doi.org/10.1039/D2CC02958H
Abstract
An electrochemical method for the azidocyanation of alkenes via 1,4-nitrile migration has been developed. This organic oxidant free method is applicable across various alkene containing cyanohydrins, and provides access to a broad range of synthetically useful 1,2-azidonitriles (28 examples). This methodology was extended to an electrochemical alkene sulfonylcyanation procedure, as well as to access a trifunctionalized hexanenitrile from a malononitrile starting material. The orthogonal derivatization of the products was also demonstrated through chemoselective transformations.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry Cardiff Catalysis Institute (CCI) |
Additional Information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence |
Publisher: | Royal Society of Chemistry |
ISSN: | 1359-7345 |
Funders: | EPSRC |
Date of First Compliant Deposit: | 26 July 2022 |
Date of Acceptance: | 6 July 2022 |
Last Modified: | 07 Jul 2023 00:45 |
URI: | https://orca.cardiff.ac.uk/id/eprint/151466 |
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