Obstetric complications and polygenic risk score: which role in predicting a severe short-term outcome in psychosis?

Tosato, Sarah, Bonetto, Chiara, Vassos, Evangelos, Lasalvia, Antonio, De Santi, Katia, Gelmetti, Margherita, Cristofalo, Doriana, Richards, Alexander and Ruggeri, Mirella 2021. Obstetric complications and polygenic risk score: which role in predicting a severe short-term outcome in psychosis? Genes 12 (12) , 1895. 10.3390/genes12121895

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Abstract

Understanding and improving the outcomes of psychosis remains a major challenge for clinical research. Obstetric complications (OCs) as a risk factor for schizophrenia (SZ) have been investigated as a potential predictor of outcomes in relation to illness severity and poorer treatment outcome, but there are less reports on first episode psychosis (FEP) patients. We test whether OCs, collected in a cohort of FEP patients, can predict illness course and psychopathology severity after 2 years from the onset. Moreover, we explore whether the SZ-polygenic risk score (PRS) would predict the illness course and whether the interaction between OCS and PRS shows a significant effect. A cohort of 264 FEP patients were assessed with standardized instruments. OCs were recorded using the Lewis–Murray scale in interviews with the patients’ mothers: 30% of them reported at least one OC. Patients with at least one OC were more likely to have a non-remitting course of illness compared to those without OCs (35.3% vs. 16.3%, p = 0.014). No association between SZ-PRS and course of illness nor evidence for a gene–environment interaction was found. In our sample, poor short-term outcomes were associated with OCs, while SZ-PRS was not a prognostic indicator of poor outcomes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Publisher:	MDPI
ISSN:	2073-4425
Date of First Compliant Deposit:	26 July 2022
Date of Acceptance:	25 November 2021
Last Modified:	14 May 2023 17:53
URI:	https://orca.cardiff.ac.uk/id/eprint/151475

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