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Molecular insights into high altitude adaption and acclimatisation of Aporrectodea caliginosa

Perry, Iain, Balazs Hernadi, Szabolcs, Cunha, Luis, Short, Stephen, Marchbank, Angela, Spurgeon, David, Orozco Ter Wengel, Pablo ORCID: and Kille, Peter ORCID: 2022. Molecular insights into high altitude adaption and acclimatisation of Aporrectodea caliginosa. Life Science Alliance 5 (11) , e202201513. 10.26508/lsa.202201513

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Here, we explore the high-altitude adaptions and acclimatisation of Aporrectodea caliginosa. Population diversity is assessed through mitochondrial barcoding, identifying closely related populations across the island of Pico (Azores). We present the first megabase N50 assembly size (1.2 Mbp) genome for A. caliginosa. High- and low-altitude populations were exposed experimentally to a range of oxygen and temperature conditions, simulating altitudinal conditions, and the transcriptomic responses explored. SNP densities are assessed to identify signatures of selective pressure and their link to differentially expressed genes. The high-altitude A. caliginosa population had lower differential expression and fewer co-expressed genes between conditions, indicating a more condition-refined epigenetic response. Genes identified as under adaptive pressure through Fst and nucleotide diversity in the high-altitude population clustered around the differentially expressed an upstream environmental response control gene, HMGB1. The high-altitude population of A. caliginosa indicated adaption and acclimatisation to high-altitude conditions and suggested resilience to extreme weather events. This mechanistic understanding could help offer a strategy in further identifying other species capable of maintaining soil fertility in extreme environments.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This article is available under a Creative Commons License (Attribution 4.0 International, as described at
Publisher: Rockefeller University Press
ISSN: 2575-1077
Funders: NERC
Date of First Compliant Deposit: 18 August 2022
Date of Acceptance: 29 July 2022
Last Modified: 06 Jan 2024 02:26

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