Pain measurement in painful skin conditions and rheumatoid arthritis randomized controlled trials: A scoping review to inform pain measurement in hidradenitis suppurativa

Hasan, Samar, Gendra, Riham, James, JaBreia, Morris, Delyth ORCID: https://orcid.org/0000-0001-8529-1270, Orenstein, Lauren and Ingram, John ORCID: https://orcid.org/0000-0002-5257-1142 2022. Pain measurement in painful skin conditions and rheumatoid arthritis randomized controlled trials: A scoping review to inform pain measurement in hidradenitis suppurativa. British Journal of Dermatology 187 (6) , pp. 846-854. 10.1111/bjd.21821

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Abstract

Background Pain is the most common and bothersome symptom experienced by people with hidradenitis suppurativa (HS) and has been prioritised as an outcome domain by the HIdradenitis SuppuraTiva cORe outcomes set International Collaboration (HISTORIC). Objectives To perform a scoping review of pain measurement in randomized control trials (RCTs) of painful skin conditions (PSCs) and use of pain numeric rating scale (NRS) and visual analogue scale (VAS) in rheumatoid arthritis (RA) RCTs to inform HISTORIC efforts to reach consensus on how to measure pain intensity in HS trials. Methods A search was conducted on several publication databases. Inclusion criteria were RCTs with a minimum of 10 participants that measured pain intensity. Results Pain NRS and VAS were used in 68% of PSCs trials. 77% and 87% of PSCs and RA RCTs did not specify the recall window. The commonest recall window in PSCs when specified was 24 hours. 33% of PSC trials assessed maximum pain intensity and 3% average pain intensity while 87% of RA trials did not provide details. Pain data were reported as mean difference by 76% of PSC trials and 75% of RA trials. 10% and 11%of PSC and RA studies reported pain as the percentage reaching a desirable state and only 1% and 2% reported number needed to treat (NNT). Conclusions While pain NRS and VAS are standard methods to measure pain intensity in PSCs, key details such as recall window are often omitted and there is no consensus on how to report pain NRS data.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RL Dermatology
Uncontrolled Keywords:	Hidradenitis suppurativa
Publisher:	Wiley
ISSN:	0007-0963
Date of First Compliant Deposit:	22 August 2022
Date of Acceptance:	11 August 2022
Last Modified:	12 Nov 2024 05:45
URI:	https://orca.cardiff.ac.uk/id/eprint/151927

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