Image phenotyping of preterm-born children using hyperpolarised 129Xe lung MRI and multiple-breath washout

Chan, Ho-Fung, Smith, Laurie J., Biancardi, Alberto M., Bray, Jody, Marshall, Helen, Hughes, Paul J.C., Collier, Guilhem J., Rao, Madhwesha, Norquay, Graham, Swift, Andrew J., Hart, Kylie, Cousins, Michael, Watkins, W. John ORCID: https://orcid.org/0000-0003-3262-6588, Wild, Jim M. and Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627 2023. Image phenotyping of preterm-born children using hyperpolarised 129Xe lung MRI and multiple-breath washout. American Journal of Respiratory and Critical Care Medicine 207 (1) , pp. 89-90. 10.1164/rccm.202203-0606OC

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Abstract

Rationale: Preterm birth is associated with low lung function in childhood, but little is known about the lung microstructure in childhood. Objectives: We assessed the differential associations between the historical diagnosis of bronchopulmonary dysplasia (BPD) and current lung function phenotypes on lung ventilation and microstructure in preterm-born children using hyperpolarised 129Xe ventilation and diffusion-weighted MRI, and multiple breath washout (MBW). Methods: Data were available from 63 children (aged 9-13 years) including 44 born preterm (≤34 weeks’ gestation) and 19 term-born controls (≥37 weeks’ gestation). Preterm-born children were classified, using spirometry, into prematurity-associated obstructive lung disease (POLD, FEV1

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	American Thoracic Society
ISSN:	1073-449X
Date of First Compliant Deposit:	23 August 2022
Date of Acceptance:	16 August 2022
Last Modified:	11 Nov 2023 16:27
URI:	https://orca.cardiff.ac.uk/id/eprint/152001

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