Increased structural connectivity in high schizotypy

Messaritaki, Eirini ORCID: https://orcid.org/0000-0002-9917-4160, Foley, Sonya ORCID: https://orcid.org/0000-0002-8390-2709, Barawi, Kali, Ettinger, Ulrich and Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049 2023. Increased structural connectivity in high schizotypy. Network Neuroscience 7 (1) , pp. 213-233. 10.1162/netn_a_00279

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Abstract

The link between brain structural connectivity and schizotypy was explored in two healthy participant cohorts, collected at two different neuroimaging centres, comprising 140 and 115 participants, respectively. The participants completed the Schizotypal Personality Questionnaire (SPQ), through which their schizotypy scores were calculated. Diffusion-MRI data were used to perform tractography and to generate the structural brain networks of the participants. The edges of the networks were weighted with the inverse radial diffusivity. Graph theoretical metrics of the default mode, sensorimotor, visual, and auditory subnetworks were derived and their correlation coefficients with the schizotypy scores were calculated. To the best of our knowledge, this is the first time that graph theoretical measures of structural brain networks are investigated in relation to schizotypy. A positive correlation was found between the schizotypy score and the mean node degree and mean clustering coefficient of the sensorimotor and the default mode subnetworks. The nodes driving these correlations were the right postcentral gyrus, the left paracentral lobule, the right superior frontal gyrus, the left parahippocampal gyrus, and the bilateral precuneus, that is, nodes that exhibit compromised functional connectivity in schizophrenia. Implications for schizophrenia and schizotypy are discussed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Medicine Psychology
Publisher:	Massachusetts Institute of Technology Press
ISSN:	2472-1751
Funders:	Wellcome Trust
Date of First Compliant Deposit:	22 September 2022
Date of Acceptance:	14 September 2022
Last Modified:	07 Sep 2023 06:19
URI:	https://orca.cardiff.ac.uk/id/eprint/152778

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