The pattern and long term follow up of covid-19 related abnormal liver blood tests

Davies, Amelia, Åsenius, Fredrika, Purcell, Frederick, Wu, Meng-San, Al-Rubaye, Ali and Alrubaiy, Laith 2022. The pattern and long term follow up of covid-19 related abnormal liver blood tests. International Journal of Scientific Research 11 (4) , pp. 1-4. 10.36106/ijsr/6020892

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Abstract

Objective: Acute COVID-19 is well-known to cause abnormalities in liver blood tests (LBTs). This study aims to identify what are the long-term implications of COVID-19 on LBTs. Methods: Aretrospective cohort study that examined the LBTs of patients admitted with COVID-19 both during acute infection and for up to one year. R factor was used to identify type of liver injury. χ² test and Fisher exact was used for statistical analysis with p<0.05 being considered signifcant. Results: Data was collected on 373 patients. During acute infection, 57.5% of patients showed at least one raised LBT(ALT, ALPand/or bilirubin). Male patients were more likely to develop LBT abnormalities than females (74.5% versus 25.5%; p<0.001). Increased LBT abnormalities seen in patients requiring ITU admission compared to those with ward based care (87% versus 51% respectively; p<0.001). During short term (1-5 months post discharge) and long-term (>5 months post discharge) follow-up, LBT abnormalities were seen in 31.3% and 24% of patients respectively. In both the acute setting and long-term follow-up, cholestatic or mixed injury types were most commonly seen (acute; 41.1%, 41.6% respectively, long-term; 50.0%, 44.4% respectively) . Discussion: Our data suggests that up to one in four patients have persistent LBT abnormalities up to one year following COVID-19. Future research is needed to investigate the clinical signicance of this LBT abnormalities and whether there are interventions, pharmacological or otherwise, that could reduce COVID-19 related liver injury, both in the acute setting, and longer-term. Summary Box: Many studies have shown that acute COVID-19 infection is commonly associated with liver dysfunction in hospitalised patients and even severe liver failure has been noted. Little however has been published about the long-term effect of COVID-19 on the liver profile blood tests. This study complements others looking at acute liver dysfunction during COVID-19 suggesting that severity of COVID-19 is a risk factor for liver blood test abnormalities. The study also suggests that younger patients when hospitalised with COVID-19 are more likely to have abnormal liver blood tests compared to their elderly counterparts. However importantly, this study suggests that around a quarter of patient hospitalised with COVID-19 have persistent liver blood test abnormalities up to one year after discharge. This observational study has highlighted the need for further research to investigate the acute and the long-term clinical signifcance of LBTabnormalities from COVID-19. This can then help identify whether there are any interventions, pharmacological or otherwise, that could reduce COVID-19 related liver injury, both in the acute setting, and longer-term

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Engineering
Publisher:	World Wide Journals
ISSN:	2277-8179
Last Modified:	10 Dec 2022 02:57
URI:	https://orca.cardiff.ac.uk/id/eprint/153161

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