Safety evaluation of employing temporal interference transcranial alternating current stimulation in human studies

Piao, Yi, Ma, Ru, Weng, Yaohao, Fan, Chuan, Xia, Xinzhao, Zhang, Wei, Zeng, Ginger Qinghong, Wang, Yan, Lu, Zhuo, Cui, Jiangtian, Wang, Xiaoxiao, Gao, Li, Qiu, Bensheng and Zhang, Xiaochu 2022. Safety evaluation of employing temporal interference transcranial alternating current stimulation in human studies. Brain Sciences 12 (9) , 1194. 10.3390/brainsci12091194

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Abstract

Temporal interference transcranial alternating current stimulation (TI-tACS) is a new technique of noninvasive brain stimulation. Previous studies have shown the effectiveness of TI-tACS in stimulating brain areas in a selective manner. However, its safety in modulating human brain neurons is still untested. In this study, 38 healthy adults were recruited to undergo a series of neurological and neuropsychological measurements regarding safety concerns before and after active (2 mA, 20/70 Hz, 30 min) or sham (0 mA, 0 Hz, 30 min) TI-tACS. The neurological and neuropsychological measurements included electroencephalography (EEG), serum neuron-specific enolase (NSE), the Montreal Cognitive Assessment (MoCA), the Purdue Pegboard Test (PPT), an abbreviated version of the California Computerized Assessment Package (A-CalCAP), a revised version of the Visual Analog Mood Scale (VAMS-R), a self-assessment scale (SAS), and a questionnaire about adverse effects (AEs). We found no significant difference between the measurements of the active and sham TI-tACS groups. Meanwhile, no serious or intolerable adverse effects were reported or observed in the active stimulation group of 19 participants. These results support that TI-tACS is safe and tolerable in terms of neurological and neuropsychological functions and adverse effects for use in human brain stimulation studies under typical transcranial electric stimulation (TES) conditions (2 mA, 20/70 Hz, 30 min).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Additional Information:	License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	MDPI
ISSN:	2076-3425
Date of First Compliant Deposit:	10 October 2022
Date of Acceptance:	2 September 2022
Last Modified:	06 Jan 2024 02:19
URI:	https://orca.cardiff.ac.uk/id/eprint/153274

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