Recent results toward the stereoselective synthesis of biologically active natural products

Dias, Luiz C., Gonzaga De Oliveira, Luciana and Meira, Paulo R. R. 2007. Recent results toward the stereoselective synthesis of biologically active natural products. Pure and Applied Chemistry 79 (2) , pp. 163-172. 10.1351/pac200779020163

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Abstract

Described herein are some examples of recent work from our laboratory that have led to the synthesisof bioactive molecules. In this paper, we will discuss our approaches to the total synthesis of (+)-cro-cacin D (1) [1], (+)-crocacin C (2) [2], and (–)–callystatin A (3) [3] (Fig. 1). We were attracted by theirfascinating biological activities, molecular architectures, and low natural abundance, which makes theirtotal synthesis extremely important. The synthetic routes were developed in order to be practical enoughto allow the isolation of the desired targets in useful amounts as well as to provide access to new analogswith potential pharmacological activities.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	International Union of Pure and Applied Chemistry
ISSN:	1365-3075
Last Modified:	14 Nov 2022 16:05
URI:	https://orca.cardiff.ac.uk/id/eprint/153691

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