Effect of dapagliflozin on exercise capacity and cardiovascular risk in patients with heart failure

Nazer, Rakan, Albratty, Mohammed, Aldhahi, Monira I., Alqurashy, Maiasa, Halawi, Maryam A. and Albarrati, Ali 2022. Effect of dapagliflozin on exercise capacity and cardiovascular risk in patients with heart failure. Healthcare 10 (11) , 2133. 10.3390/healthcare10112133

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Abstract

Heart failure (HF) is a serious disorder that affects millions of people worldwide, with a high rate of exercise intolerance, rehospitalization, and death. HF has many underlying causes, including type 2 diabetes mellitus (T2DM), which corresponds with high mortality and short survival among patients with HF. Numerous studies have shown the crucial role of gliflozins, a new generation of blood glucose-lowering medications, in cardiac remodeling, with beneficial impacts on exercise capacity and cardiovascular (CV) mortality, even in non-diabetic individuals. The foundational CV-protective frameworks of these agents are intricate and multifaceted. Dapagliflozin is a new widely used drug and a valuable alternative for patients with T2DM and CV risk factors. Dapagliflozin was approved by the Food and Drug Administration (FDA) in 2019 to lower the risk of HF hospitalization in patients with concurrent T2DM and CV disease or associated risk factors. However, the effects of this new drug on exercise capacity and CV risk still need to be elucidated. The primary objective of this review is to summarize the effect of dapagliflozin on exercise capacity and CV risk in patients with HF.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	MDPI
Date of First Compliant Deposit:	17 November 2022
Date of Acceptance:	21 October 2022
Last Modified:	30 May 2023 00:36
URI:	https://orca.cardiff.ac.uk/id/eprint/154279

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