The association of OSR-1 between vascular dysfunction and hypertension in polycystic kidney disease

Eroglu, Eray, Kocyigit, Ismail, Taheri, Serpil, Zararsiz, Gokmen, Sener, Elif, Uzun, Ilknur, Imamoglu, Hakan, Mehmetbeyoglu, Ecmel, Unal, Aydin, Korkmaz, Kezban, Sipahioglu, Murat, Oymak, Oktay and Tokgoz, Bulent 2018. The association of OSR-1 between vascular dysfunction and hypertension in polycystic kidney disease. Nephrology Dialysis Transplantation 33 (Suppl) , i65-i65. 10.1093/ndt/gfy104.FP053

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Abstract

INTRODUCTION AND AIMS: Autosomal dominant polycystic kidney disease (ADPKD) is associated withoxidative stress, and hypertension development before renal function decline and cardiovascular disease development. Oxidative stress responsive kinase-1 (OSR-1) participates in the signaling regulating Na+ transport during oxidative stress and also plays a role in the regulation of cell volume and blood pressure. Therefore we aimed to investigate the potential role of OSR-1 in ADPKD patients. METHODS: Eighty ADPKD patients and eighty matched healthy controls were enrolled to this cross-sectional study. Twenty-four-hour ambulatory blood pressure monitoring was conducted in all participants. Blood samples were taken after 12-h fasting for the measurement of biochemical parameters and serum OSR-1 gene expression. Vascular dysfunction was assessed using ischemia-induced forearm flow-mediated vasodilation (FMD). RESULTS: Briefly, of the 80 ADPKD patients, 41(51%) were male and 53(66%) of them were hypertensive. The 80 controls mean age was 35.3±12.6 and 37(46%) of them were male. There were significant differences in serum OSR-1 gene expression between the ADPKD patients and the control subjects. Serum OSR-1 gene expression was also significantly different in ADPKD patients with hypertension in comparison with normotensive ones and significantly inversely correlated with FMD (p<0.05)(Figure-1). CONCLUSIONS: Serum OSR-1 gene expression was increased in patients with ADPKD thanhealthy subjects. Low estimated glomerular filtration rate (eGFR), OSR- 1 gene expression, total kidney volume (TKV) and high density lipoprotein (HDL) were also independently associated with hypertension in ADPKD patients. Also, vascular dysfunction which is monitored by FMD is inversely correlated with OSR-1 gene expression levels.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Oxford University Press
ISSN:	0931-0509
Last Modified:	30 Jun 2023 11:35
URI:	https://orca.cardiff.ac.uk/id/eprint/154373

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