Advances in direct T-cell alloreactivity: Function, avidity, biophysics and structure

Smith, C., Miles, J.J. and Khanna, R. 2022. Advances in direct T-cell alloreactivity: Function, avidity, biophysics and structure. American Journal of Transplantation 12 (1) , pp. 15-26. 10.1111/j.1600-6143.2011.03863.x

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Abstract

Although T-cell-based adaptive immunity plays a crucial role in protection against infectious pathogens and uncontrolled outgrowth of malignant cells, a large portion of these T cells are also capable of responding to allogeneic HLA molecules, violating the paradigm of self-major histocompatibility complex (MHC) restriction. Recent studies have provided insights into the mechanisms by which these T cells recognize allogeneic targets. The role of antiviral T cells in direct alloreactivity through peptide-dependent molecular mimicry and alternate peptide-MHC docking modes has emerged as major models for the human alloresponse. Here, we review in depth recent advances in this field and discuss how molecular interactions between T cells and HLA molecules drive the activation of these effector cells and its potential implications for alloreactivity in human transplantation.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by-nc-nd/4.0/, Start Date: 2022-12-03
Publisher:	Wiley
ISSN:	1600-6135
Date of First Compliant Deposit:	3 January 2023
Date of Acceptance:	11 October 2011
Last Modified:	10 Jun 2023 06:53
URI:	https://orca.cardiff.ac.uk/id/eprint/155359

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