Fabrication of a positional brain shift phantom through the utilization of the frozen intermediate hydrogel state

Potts, Matthew R., Bennion, Nicholas J., Zappala, Stefano, Marshall, David ORCID: https://orcid.org/0000-0003-2789-1395, Harrison, Rob and Evans, Sam L. ORCID: https://orcid.org/0000-0003-3664-2569 2023. Fabrication of a positional brain shift phantom through the utilization of the frozen intermediate hydrogel state. Journal of the Mechanical Behavior of Biomedical Materials 140 , 105704. 10.1016/j.jmbbm.2023.105704

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Abstract

Synthetic models (phantoms) of the brain-skull system are useful tools for the study of surgical events that are otherwise difficult to study directly in humans. To date, very few studies can be found which replicate the full anatomical brain-skull system. Such models are required to study the more global mechanical events that can occur in neurosurgery, such as positional brain shift. Presented in this work is a novel workflow for the fabrication of a biofidelic brain-skull phantom which features a full hydrogel brain with fluid-filled ventricle/fissure spaces, elastomer dural septa and fluid-filled skull. Central to this workflow is the utilization of the frozen intermediate curing state of an established brain tissue surrogate, which allows for a novel moulding and skull installation approach that permits a much fuller recreation of the anatomy. The mechanical realism of the phantom was validated through indentation testing of the phantom's brain and simulation of the supine to prone brain shift event, while the geometric realism was validated through magnetic resonance imaging. The developed phantom captured a novel measurement of the supine to prone brain shift event with a magnitude that accurately reproduces that seen in the literature.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Engineering Computer Science & Informatics
Publisher:	Elsevier
ISSN:	1751-6161
Date of First Compliant Deposit:	6 February 2023
Date of Acceptance:	1 February 2023
Last Modified:	05 May 2023 20:16
URI:	https://orca.cardiff.ac.uk/id/eprint/156496

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