Bryson, K. J., Wei, Xiao-Qing ![]() |
Abstract
Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Dentistry |
Uncontrolled Keywords: | Interleukin-18; Leishmania mexicana; Th2 |
Publisher: | Elsevier |
ISSN: | 1286-4579 |
Last Modified: | 18 Oct 2022 13:53 |
URI: | https://orca.cardiff.ac.uk/id/eprint/15792 |
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