Sleep waves in a large‐scale corticothalamic model constrained by activities intrinsic to neocortical networks and single thalamic neurons

Dervinis, Martynas and Crunelli, Vincenzo ORCID: https://orcid.org/0000-0001-7154-9752 2024. Sleep waves in a large‐scale corticothalamic model constrained by activities intrinsic to neocortical networks and single thalamic neurons. CNS Neuroscience and Therapeutics 30 (3) , e14206. 10.1111/cns.14206

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Abstract

Aim: Many biophysical and non‐biophysical models have been able to reproduce the corticothalamic activities underlying different EEG sleep rhythms but none of them included the known ability of neocortical networks and single thalamic neurons to generate some of these waves intrinsically. Methods: We built a large‐scale corticothalamic model with a high fidelity in anatomical connectivity consisting of a single cortical column and first‐ and higher‐order thalamic nuclei. The model is constrained by different neocortical excitatory and inhibitory neuronal populations eliciting slow (<1 Hz) oscillations and by thalamic neurons generating sleep waves when isolated from the neocortex. Results: Our model faithfully reproduces all EEG sleep waves and the transition from a desynchronized EEG to spindles, slow (<1 Hz) oscillations, and delta waves by progressively increasing neuronal membrane hyperpolarization as it occurs in the intact brain. Moreover, our model shows that slow (<1 Hz) waves most often start in a small assembly of thalamocortical neurons though they can also originate in cortical layer 5. Moreover, the input of thalamocortical neurons increases the frequency of EEG slow (<1 Hz) waves compared to those generated by isolated cortical networks. Conclusion: Our simulations challenge current mechanistic understanding of the temporal dynamics of sleep wave generation and suggest testable predictions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/
Publisher:	Wiley Open Access
ISSN:	1755-5930
Funders:	MRC
Date of First Compliant Deposit:	20 April 2023
Date of Acceptance:	24 March 2023
Last Modified:	18 Apr 2024 13:39
URI:	https://orca.cardiff.ac.uk/id/eprint/158960

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