Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Methods for studying activation of matrix metalloproteinases

Knauper, Vera and Murphy, Gillian 2010. Methods for studying activation of matrix metalloproteinases. Methods Mol Biol 622 , pp. 233-43. 10.1007/978-1-60327-299-5_14

Full text not available from this repository.


The degradation of the extracellular matrix during development and in disease is thought to result from the combined action of several proteolytic enzyme systems, including the matrix metalloproteinases (MMPs), serine proteinases, and cysteine proteinases. The majority of the soluble MMPs are synthesized as proenzymes which require extracellular activation in order to gain proteolytic activity and the analysis of their activation mechanism is a prerequisite for understanding MMP-mediated proteolysis.The emphasis of this chapter is the provision of the experimental tools to study MMP activation in vitro and in cellular model systems. Hence, we use the activation of procollagenase-3 (proMMP-13) and progelatinase A (proMMP-2) as examples of the methods used.

Item Type: Article
Schools: Dentistry
ISSN: 1940-6029
Last Modified: 04 Jun 2017 03:02

Citation Data

Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item