Hutter, Jana, Slator, Paddy J.  ORCID: https://orcid.org/0000-0001-6967-989X, Jackson, Laurence, Gomes, Ana Dos Santos, Ho, Alison, Story, Lisa, O?Muircheartaigh, Jonathan, Teixeira, Rui P. A. G., Chappell, Lucy C., Alexander, Daniel C., Rutherford, Mary A. and Hajnal, Joseph V.
2018.
Multi-modal functional MRI to explore placental function over gestation.
Magnetic Resonance in Medicine
81
(2)
, pp. 1191-1204.
10.1002/mrm.27447
|
Abstract
Purpose To investigate, visualize and quantify the physiology of the human placenta in several dimensions - functional, temporal over gestation, and spatial over the whole organ. Methods Bespoke MRI techniques, combining a rich diffusion protocol, anatomical data and T2* mapping together with a multi-modal pipeline including motion correction and extracted quantitative features were developed and employed on pregnant women between 22 and 38 weeks gestational age including two pregnancies diagnosed with pre-eclampsia. Results A multi-faceted assessment was demonstrated showing trends of increasing lacunarity, and decreasing T2* and diffusivity over gestation. Conclusions The obtained multi-modal acquisition and quantification shows promising opportunities for studying evolution, adaptation and compensation processes.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Computer Science & Informatics |
| Publisher: | Wiley |
| ISSN: | 0740-3194 |
| Date of Acceptance: | 12 June 2018 |
| Last Modified: | 06 Jul 2023 10:00 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/160733 |
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