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Multi-modal functional MRI to explore placental function over gestation

Hutter, Jana, Slator, Paddy J. ORCID:, Jackson, Laurence, Gomes, Ana Dos Santos, Ho, Alison, Story, Lisa, O?Muircheartaigh, Jonathan, Teixeira, Rui P. A. G., Chappell, Lucy C., Alexander, Daniel C., Rutherford, Mary A. and Hajnal, Joseph V. 2018. Multi-modal functional MRI to explore placental function over gestation. Magnetic Resonance in Medicine 81 (2) , pp. 1191-1204. 10.1002/mrm.27447

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Purpose To investigate, visualize and quantify the physiology of the human placenta in several dimensions - functional, temporal over gestation, and spatial over the whole organ. Methods Bespoke MRI techniques, combining a rich diffusion protocol, anatomical data and T2* mapping together with a multi-modal pipeline including motion correction and extracted quantitative features were developed and employed on pregnant women between 22 and 38 weeks gestational age including two pregnancies diagnosed with pre-eclampsia. Results A multi-faceted assessment was demonstrated showing trends of increasing lacunarity, and decreasing T2* and diffusivity over gestation. Conclusions The obtained multi-modal acquisition and quantification shows promising opportunities for studying evolution, adaptation and compensation processes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Computer Science & Informatics
Publisher: Wiley
ISSN: 0740-3194
Date of Acceptance: 12 June 2018
Last Modified: 06 Jul 2023 10:00

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