Inactivation of human plasma α1-proteinase inhibitor by human PMN leucocyte collagenase

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Reinke, Heinz and Tschesche, Harald 1990. Inactivation of human plasma α1-proteinase inhibitor by human PMN leucocyte collagenase. FEBS Letters 263 (2) , pp. 355-357. 10.1016/0014-5793(90)81412-H

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Abstract

Highly purified human polymorphonuelear leucocyte collagenase cleaved human α-1-proteinase inhibitor (α1-PI) at the carboxyl site of Phe352 (P7). The inhibitor was thereby rapidly inactivated and generated a primary degradation product as shown by reverse-phase HPLC and N-terminal sequencing. Prolonged incubation of the modified inhibitor with polymorphonuclear leucocyte collagenase led to the generation of a secondary degradation product with additional cleavage at the carboxyl site of Pro357 (P2).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Publisher:	Federation of European Biochemical Societies
ISSN:	1873-3468
Last Modified:	31 Aug 2023 15:16
URI:	https://orca.cardiff.ac.uk/id/eprint/161611

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