Different binding capacities of influenza A and Sendai viruses to gangliosides from human granulocytes

Muthing, Johannes, Unland, Frank, Heitmann, Dagmar, Orlich, Michaela, Hanisch, Franz-Georg, Peter-Katalinić, Jasna, Knäuper, Vera, Tschesche, Harald, Kelm, Sørge, Schauer, Roland and Lehmann, Jürgen 1993. Different binding capacities of influenza A and Sendai viruses to gangliosides from human granulocytes. Glycoconjugate Journal 10 (1) , pp. 120-126. 10.1007/BF00731196

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Abstract

The structures of gangliosides from human granulocytes were elucidated by fast atom bombardment mass spectrometry and by gas chromatography/mass spectrometry as their partially methylated alditol acetates. In human granulocytes besides GM3 (II3Neu5Ac-LacCer), neolacto-series gangliosides (IV3Neu5Ac-nLcOse4Cer, IV6Neu5Ac-nLcOse4Cer and VI3Neu5Ac-nLcOse6Cer) containing C24:1, and to some extent C22:0; and C16:0 fatty acid in their respective ceramide portions, were identified as major components. In this study we demonstrate that gangliosides from human granulocytes, the second most abundant cells in peripheral blood, can serve as receptors for influenza viruses A/PR/8/34 (H1N1), A/X-31 (H3N2), and a parainfluenza virus Sendai virus (HNF1, Z-strain). Viruses were found to exhibit specific adhesion to terminal Neu5Acα2-3Gal and/or Neu5Acα2-6Gal sequences as well as depending on the chain length of ganglioside carbohydrate backbones from human granulocytes, these important effector cells which represent the first line of defence in immunologically mediated reactions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Publisher:	Springer
ISSN:	0282-0080
Last Modified:	31 Aug 2023 12:00
URI:	https://orca.cardiff.ac.uk/id/eprint/161628

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