Developments in fungal serology

White, P. Lewis 2023. Developments in fungal serology. Current Fungal Infection Reports 17 (2) , 132–143. 10.1007/s12281-023-00462-4

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Abstract

Purpose of Review The true incidence of fungal disease is hampered by conventionally poor diagnostic tests, limited access to advanced diagnostics, and limited surveillance. The availability of serological testing has been available for over two decades and generally underpins the modern diagnosis of the most common forms of fungal disease. This review will focus on technical developments of serological tests for the diagnosis of fungal disease, describing advances in clinical performance when available. Recent Findings Despite their longevity, technical, clinical, and performance limitations remain, and tests specific for fungal pathogens outside the main pathogens are lacking. The availability of LFA and automated systems, capable of running multiple different tests, represents significant developments, but clinical performance data is variable and limited. Summary Fungal serology has significantly advanced the diagnosis of the main fungal infections, with LFA availability increasing accessibility to testing. Combination testing has the potential to overcome performance limitations.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Springer
ISSN:	1936-3761
Date of First Compliant Deposit:	18 August 2023
Date of Acceptance:	20 March 2023
Last Modified:	23 Aug 2023 02:46
URI:	https://orca.cardiff.ac.uk/id/eprint/161908

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