Risk of organism acquisition from prior room occupants: An updated systematic review

Mitchell, Brett G., McDonagh, Julee, Dancer, Stephanie J., Ford, Sindi, Sim, Jenny, Thottiyil Sultanmuhammed Abdul Khadar, Bismi, Russo, Philip L., Maillard, Jean-Yves ORCID: https://orcid.org/0000-0002-8617-9288, Rawson, Helen, Browne, Katrina and Kiernan, Martin 2023. Risk of organism acquisition from prior room occupants: An updated systematic review. Infection, Disease & Health 28 (4) , pp. 290-297. 10.1016/j.idh.2023.06.001

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Abstract

Background Evidence from a previous systematic review indicates that patients admitted to a room where the previous occupant had a multidrug-resistant bacterial infection resulted in an increased risk of subsequent colonisation and infection with the same organism for the next room occupant. In this paper, we have sought to expand and update this review. Methods A systematic review and meta-analysis was undertaken. A search using Medline/PubMed, Cochrane and CINHAL databases was conducted. Risk of bias was assessed by the ROB-2 tool for randomised control studies and ROBIN-I for non-randomised studies. Results From 5175 identified, 12 papers from 11 studies were included in the review for analysis. From 28,299 patients who were admitted into a room where the prior room occupant had any of the organisms of interest, 651 (2.3%) were shown to acquire the same species of organism. In contrast, 981,865 patients were admitted to a room where the prior occupant did not have an organism of interest, 3818 (0.39%) acquired an organism(s). The pooled acquisition odds ratio (OR) for all the organisms across all studies was 2.45 (95% CI: 1.53–3.93]. There was heterogeneity between the studies (I2 89%, P < 0.001). Conclusion The pooled OR for all the pathogens in this latest review has increased since the original review. Findings from our review provide some evidence to help inform a risk management approach when determining patient room allocation. The risk of pathogen acquisition appears to remain high, supporting the need for continued investment in this area.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Elsevier
ISSN:	2468-0451
Date of First Compliant Deposit:	30 August 2023
Date of Acceptance:	26 May 2023
Last Modified:	28 Nov 2023 15:26
URI:	https://orca.cardiff.ac.uk/id/eprint/162113

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