Proteomics: from single molecules to biological pathways.

Langley, Sarah R. ORCID: https://orcid.org/0000-0003-4419-476X, Dwyer, Joseph, Drozdov, Ignat, Yin, Xiaoke and Mayr, Manuel 2013. Proteomics: from single molecules to biological pathways. Cardiovascular Research 97 (4) , pp. 612-622. 10.1093/cvr/cvs346

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Abstract

The conventional reductionist approach to cardiovascular research investigates individual candidate factors or linear signalling pathways but ignores more complex interactions in biological systems. The advent of molecular profiling technologies that focus on a global characterization of whole complements allows an exploration of the interconnectivity of pathways during pathophysiologically relevant processes, but has brought about the issue of statistical analysis and data integration. Proteins identified by differential expression as well as those in protein–protein interaction networks identified through experiments and through computational modelling techniques can be used as an initial starting point for functional analyses. In combination with other ‘-omics’ technologies, such as transcriptomics and metabolomics, proteomics explores different aspects of disease, and the different pillars of observations facilitate the data integration in disease-specific networks. Ultimately, a systems biology approach may advance our understanding of cardiovascular disease processes at a ‘biological pathway’ instead of a ‘single molecule’ level and accelerate progress towards disease-modifying interventions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Oxford University Press
ISSN:	0008-6363
Date of Acceptance:	15 November 2012
Last Modified:	05 Sep 2023 12:45
URI:	https://orca.cardiff.ac.uk/id/eprint/162157

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