A convenient synthesis of novel hydrazones and osazones of 2-hydrazino-3-phenyl-4(3H)-quinazolinone

Abdel-Megeed, Mohamed F., El-Hiti, Gamal A., Saleh, Mohamed A., Abdo, Mohamed A. and Awadalla, Sahar E. 1999. A convenient synthesis of novel hydrazones and osazones of 2-hydrazino-3-phenyl-4(3H)-quinazolinone. Revue Roumaine de Chimie 44 (1) , pp. 67-76.

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Abstract

A series of the hydrazones 3 was prepared in very good yields by the reaction of 2-hydrazino-3-phenyl-4(3H)-quinazolinone (1) with monosaccharaides 2. Acetylation of the hydrazones using acetic anhydride in the presence of pyridine at room temperature gave the corresponding acetyl derivatives 4 in excellent yields. The reaction of three mole equivalents of 1 with one equivalent of monosaccharaides 2 in acetic acid afforded the corresponding osazones 5 in poor yields. Acetylation of the osazones using acetic anhydride in the presence of pyridine at room temperature afforded the corresponding acetyl derivatives 6 in good yields.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
ISSN:	0035-3930
Last Modified:	19 Mar 2016 22:26
URI:	https://orca.cardiff.ac.uk/id/eprint/16226

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