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Tracking cardiovascular comorbidity in models of chronic inflammatory disease

Morrin, Aisling S., Eastham, Simon, Williams, Anwen S. ORCID: and Jones, Gareth W. 2023. Tracking cardiovascular comorbidity in models of chronic inflammatory disease. Jenkins, Brendan J., ed. Inflammation and Cancer, Vol. 2691. Methods in Molecular Biology, New York, NY, USA: Springer, pp. 123-137. (10.1007/978-1-0716-3331-1_10)

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Immune-mediated inflammatory diseases (IMIDs) are commonly associated with complex coexisting conditions, and cardiovascular comorbidities are a common cause of mortality in systemic inflammation. Experimental models of disease provide an opportunity to dissect inflammatory mechanisms that promote damage to vascular tissues affected by comorbidity. Here, we describe methods to recover the thoracic aorta from mice during experimental inflammatory arthritis and assess vascular constriction responses by isometric tension myography. To complement the assessment of functional changes in the vasculature during inflammatory arthritis, we also outline a method to characterize vascular inflammation by immunohistochemistry.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Springer
ISBN: 9781071633304
ISSN: 1064-3745
Date of First Compliant Deposit: 12 September 2023
Date of Acceptance: 25 June 2023
Last Modified: 14 Sep 2023 01:30

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