Evaluating the safety and efficacy of dexmedetomidine as a sedative drug among mechanically ventilated adult critically ill patients

Selvaraj, Nelson 2014. Evaluating the safety and efficacy of dexmedetomidine as a sedative drug among mechanically ventilated adult critically ill patients. Cardiff University.

Full text not available from this repository.

Abstract

The objective of this extended literature review was to evaluate the efficacy and safety of Dexmedetomidine as a sedative drug among mechanically ventilated adult critically ill patients. Efficacy outcomes such as the ability of Dexmedetomidine to achieve target sedation score, duration of mechanical ventilation (MV), length of intensive care unit (ICU) stay, and incidence of delirium were evaluated. In general, some of the studies reviewed were small, have poor methodological rigour and suffered from a high risk of bias. Furthermore, variations in the doses and heterogeneous protocols were used making generalisation difficult. Evidence suggests that Dexmedetomidine may be efficacious only for light to moderate sedation. The beneficial effect of DEX compared with other conventional sedative agents on the duration of MV and incidence of delirium was not consistently demonstrated in the available evidence. Furthermore, the reduction in the duration of MV did not always translate to reduced duration of ICU stay. All most all studies evaluated safety profile in relation to side effects such as hypotension and bradycardia. The incidence of bradycardia and hypotension with DEX was high, especially when a loading dose or high maintenance dose infusion were used. Currently, there is no good quality evidence suggesting that Dexmedetomidine was associated with better mortality outcome although many studies did not evaluate mortality outcome as primary endpoint.

Item Type:	Thesis (Other)
Date Type:	Completion
Status:	Unpublished
Schools:	Medicine
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RT Nursing
Last Modified:	18 Sep 2023 10:56
URI:	https://orca.cardiff.ac.uk/id/eprint/162551

Actions (repository staff only)

Edit Item