Spring, J., Beck, Konrad  ORCID: https://orcid.org/0000-0001-5098-9484 and Chiquet-Ehrismann, R.
1989.
Two contrary functions of tenascin: dissection of the active sites by recombinant tenascin fragments.
Cell
59
(2)
, pp. 325-334.
10.1016/0092-8674(89)90294-8
|
Abstract
A structural and functional model of tenascin was elaborated using recombinant parts of three alternatively spliced tenascin variants and anti-tenascin monoclonal antibodies. The fusion proteins were compared with intact tenascin for their functions and by electron microscopy. A strong cell binding site was localized within 104 amino acids. This fragment also contains the epitope of the monoclonal antibody anti-Tn68, which inhibits cell attachment to tenascin and binds near the tips of the six arms of tenascin. In contrast, constructs containing the 13 1/2 EGF-like repeats of tenascin showed an antiadhesive effect. The coexistence of the two contrary signals on the same molecule might be responsible for the versatile features of tenascin.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Dentistry |
| Subjects: | Q Science > QD Chemistry |
| Publisher: | Elsevier |
| ISSN: | 0092-8674 |
| Last Modified: | 05 Jan 2024 08:12 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/16300 |
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