O2‐09‐05: Coronary artery bypass graft surgery and Dementia risk in the cardiovascular health study

Kuzma, Elzbieta, Airdrie, Jac ORCID: https://orcid.org/0000-0002-1619-3172, Littlejohns, Thomas J., Lourida, Ilianna, Thompson-Coon, Jo, Lang, Iain A., Scrobotovici, Monica, Thacker, Evan, Fitzpatrick, Annette L., Kuller, Lewis H., Lopez, Oscar L., Longstreth Jr, W.T., Ukoumunne, Obioha and Llewellyn, David J. 2016. O2‐09‐05: Coronary artery bypass graft surgery and Dementia risk in the cardiovascular health study. Presented at: Alzheimer's Association International Conference (AAIC): Oral Sessions O2-09: Epidemiology: Vascular Pathology and Cognitive Impairment, Toronto, 22 - 28 July 2016. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. , vol.12 (7S Par) Wiley, P248-P249. 10.1016/j.jalz.2016.06.446

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Abstract

Background Coronary artery bypass graft surgery (CABG) is increasingly used in the elderly as a successful treatment for coronary artery disease. However, the long-term association between CABG and dementia risk remains unclear. Methods We used data from the US Cardiovascular Health Study, a large, prospective population-based study and included 3155 older adults, who were dementia free and had their history of CABG assessed at baseline. Participants were followed up for a median of 6 years (interquartile range 4.7-6.5). We used Cox proportional hazards regression models to examine the association between history of CABG and time to incident all-cause dementia, Alzheimer’s disease (AD), vascular dementia (VaD) and mixed dementia. Our models were adjusted for age, sex, ethnicity, education, baseline hypertension, diabetes and clinical or subclinical cardiovascular disease. Results History of CABG almost doubled the risk of all-cause dementia (hazard ratio [HR] = 1.93, 95% confidence interval [CI] = 1.36-2.74) and almost tripled the risk of mixed dementia (HR = 2.73, 95% CI = 1.55-4.80) compared to no history of CABG. The associations with AD (HR = 1.71, 95% CI = 0.98-2.98) and VaD (HR = 1.42, 95% CI = 0.56-3.65) were in the same direction though statistically not significant. When we compared the risk of incident all-cause dementia and its subtypes in those with history of CABG to those with history of percutaneous coronary intervention, HRs suggested that history of CABG may be associated with a higher though statistically not significant risk of all-cause dementia and mixed dementia. However, these analyses were underpowered due to a small number of participants in the comparison group. Conclusions History of CABG is a long-term risk factor for all-cause dementia and mixed dementia. Further research is needed to clarify the mechanisms of this association and to compare CABG to alternative treatments strategies in terms of long-term dementia risk.

Item Type:	Conference or Workshop Item (Speech)
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Wiley
ISSN:	1552-5260
Last Modified:	21 Nov 2023 15:15
URI:	https://orca.cardiff.ac.uk/id/eprint/163643

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