Coronary artery bypass graft surgery and Dementia risk in the cardiovascular health study

Kuzma, Elzbieta, Airdrie, Jac ORCID: https://orcid.org/0000-0002-1619-3172, Littlejohns, Thomas J., Lourida, Ilianna, Thompson-Coon, Jo, Lang, Iain A., Scrobotovici, Monica, Thacker, Evan L., Fitzpatrick, Annette, Kuller, Lewis H., Lopez, Oscar L., Longstreth, William T. Jr, Ukoumunne, Obioha C. and Llewellyn, David J. 2017. Coronary artery bypass graft surgery and Dementia risk in the cardiovascular health study. Alzheimer Disease and Associated Disorders 31 (2) , pp. 120-127. 10.1097/wad.0000000000000191

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Abstract

Introduction: The association between history of coronary artery bypass graft surgery (CABG) and dementia risk remains unclear. Methods: We conducted a prospective cohort analysis using data on 3155 elderly adults free from prevalent dementia from the US population-based Cardiovascular Health Study (CHS) with adjudicated incident all-cause dementia, Alzheimer disease (AD), vascular dementia (VaD), and mixed dementia. Results: In the CHS, the hazard ratio (HR) for all-cause dementia was 1.93 [95% confidence interval (CI), 1.36-2.74] for those with CABG history compared with those with no CABG history after adjustment for potential confounders. Similar HRs were observed for AD (HR=1.71; 95% CI, 0.98-2.98), VaD (HR=1.42; 95% CI, 0.56-3.65), and mixed dementia (HR=2.73; 95% CI, 1.55-4.80). The same pattern of results was observed when these CHS findings were pooled with a prior prospective study, the pooled HRs were 1.96 (95% CI, 1.42-2.69) for all-cause dementia, 1.71 (95% CI, 1.04-2.79) for AD and 2.20 (95% CI, 0.78-6.19) for VaD. Discussion: Our results suggest CABG history is associated with long-term dementia risk. Further investigation is warranted to examine the causal mechanisms which may explain this relationship or whether the association reflects differences in coronary artery disease severity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0893-0341
Last Modified:	21 Nov 2023 15:00
URI:	https://orca.cardiff.ac.uk/id/eprint/163644

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