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Diffusion‐weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling

Ligneul, Clémence, Najac, Chloé, Döring, André, Beaulieu, Christian, Branzoli, Francesca, Clarke, William T., Cudalbu, Cristina, Genovese, Guglielmo, Jbabdi, Saad, Jelescu, Ileana, Karampinos, Dimitrios, Kreis, Roland, Lundell, Henrik, Marjańska, Małgorzata, Möller, Harald E., Mosso, Jessie, Mougel, Eloïse, Posse, Stefan, Ruschke, Stefan, Simsek, Kadir, Szczepankiewicz, Filip, Tal, Assaf, Tax, Chantal ORCID:, Oeltzschner, Georg, Palombo, Marco ORCID:, Ronen, Itamar and Valette, Julien 2024. Diffusion‐weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling. Magnetic Resonance in Medicine 91 (3) , pp. 860-885. 10.1002/mrm.29877

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Brain cell structure and function reflect neurodevelopment, plasticity, and aging; and changes can help flag pathological processes such as neurodegeneration and neuroinflammation. Accurate and quantitative methods to noninvasively disentangle cellular structural features are needed and are a substantial focus of brain research. Diffusion‐weighted MRS (dMRS) gives access to diffusion properties of endogenous intracellular brain metabolites that are preferentially located inside specific brain cell populations. Despite its great potential, dMRS remains a challenging technique on all levels: from the data acquisition to the analysis, quantification, modeling, and interpretation of results. These challenges were the motivation behind the organization of the Lorentz Center workshop on “Best Practices & Tools for Diffusion MR Spectroscopy” held in Leiden, the Netherlands, in September 2021. During the workshop, the dMRS community established a set of recommendations to execute robust dMRS studies. This paper provides a description of the steps needed for acquiring, processing, fitting, and modeling dMRS data, and provides links to useful resources.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Physics and Astronomy
Cardiff University Brain Research Imaging Centre (CUBRIC)
Additional Information: License information from Publisher: LICENSE 1: URL:
Publisher: Wiley
ISSN: 0740-3194
Date of First Compliant Deposit: 13 November 2023
Date of Acceptance: 8 September 2023
Last Modified: 15 Jan 2024 10:56

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