Polygenic variation underlying educational attainment and attention-deficit/hyperactivity disorder indexes behavior ratings of executive functions in child psychiatry outpatients

Capawana, Michael, Vuijk, Pieter, Martin, Joanna ORCID: https://orcid.org/0000-0002-8911-3479, Pollastri, Alisha, Forchelli, Gina, Woscoboinik, Georgia, Tremblay, Sonia, Wolfe, Lauren, Braaten, Ellen and Doyle, Alysa 2024. Polygenic variation underlying educational attainment and attention-deficit/hyperactivity disorder indexes behavior ratings of executive functions in child psychiatry outpatients. Journal of Attention Disorders 28 (5) 10.1177/10870547231219763

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Abstract

Objective: We leveraged common genetic variation underlying ADHD, educational attainment (EA) and cognition (COG) to understand the nature of the Behavior Rating Inventory for Executive Functions (BRIEF) and its relationship to academic functioning. Method: Participants were 991 youth, ages 7 to 17, consecutively referred for neuropsychiatric evaluation. Polygenic scores (PGS) for ADHD, EA, and COG were related to the BRIEF using regression analyses. Structural equation models were used to examine the associations between the PGS, BRIEF and academic outcomes (math, reading, and special education services [EDPLAN]). Results: After modeling the PGS together, only the EA and ADHD PGS significantly associated with the BRIEF. The BRIEF partially mediated the relationships between EA PGS with math and EDPLAN and fully mediated the relationship between ADHD PGS and EDPLAN. Conclusion: Genetic data extend evidence that the BRIEF measures a construct relevant to educational success that differs from what is indexed by cognitive testing.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	SAGE Publications
ISSN:	1087-0547
Date of First Compliant Deposit:	21 November 2023
Date of Acceptance:	13 November 2023
Last Modified:	07 Nov 2024 16:00
URI:	https://orca.cardiff.ac.uk/id/eprint/164120

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