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The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice

Roberts, Luke D., Hornsby, Amanda K.E., Thomas, Alanna, Sassi, Martina, Kinzett, Aimee, Hsiao, Nathan, David, Bethan R., Good, Mark ORCID:, Wells, Timothy ORCID: and Davies, Jeffrey S. 2023. The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice. EMBO Reports 24 (12) , e57269. 10.15252/embr.202357269

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New neurones are generated throughout life in the mammalian brain in a process known as adult hippocampal neurogenesis (AHN). Since this phenomenon grants a high degree of neuroplasticity influencing learning and memory, identifying factors that regulate AHN may be important for ameliorating age‐related cognitive decline. Calorie restriction (CR) has been shown to enhance AHN and improve memory, mediated by the stomach hormone, ghrelin. Intermittent fasting (IF), a dietary strategy offering more flexibility than conventional CR, has also been shown to promote aspects of AHN. The 5:2 diet is a popular form of IF; however, its effects on AHN are not well characterised. To address this, we quantified AHN in adolescent and adult wild‐type and ghrelin‐receptor‐deficient mice following 6 weeks on a 5:2 diet. We report an age‐related decline in neurogenic processes. However, the 5:2 diet does not increase AHN nor enhance memory performance, suggesting that this specific form of IF is ineffective in promoting brain plasticity to support learning.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Business (Including Economics)
Additional Information: License information from Publisher: LICENSE 1: URL:
Publisher: Wiley
ISSN: 1469-221X
Date of First Compliant Deposit: 22 November 2023
Date of Acceptance: 30 October 2023
Last Modified: 23 Jan 2024 16:01

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