Association of occupational dysfunction and hospital admissions with different polygenic profiles in bipolar disorder

Jonsson, Lina, Horbeck, Elin, Primerano, Amedeo, Song, Jie, Karlsson, Robert, Smedler, Erik, Gordon-Smith, Katherine, Jones, Lisa, Craddock, Nicholas ORCID: https://orcid.org/0000-0003-2171-0610, Jones, Ian ORCID: https://orcid.org/0000-0001-5821-5889, Sullivan, Patrick, Palsson, Erik, Di Florio, Arianna ORCID: https://orcid.org/0000-0003-0338-2748, Sparding, Timea and Landen, Mikael 2024. Association of occupational dysfunction and hospital admissions with different polygenic profiles in bipolar disorder. The American Journal of Psychiatry 181 (7) , pp. 620-629. 10.1176/appi.ajp.20230073

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Abstract

Objective: Many but not all persons with bipolar disorder require hospital care because of severe mood episodes. Likewise, some but not all patients experience long-term occupational dysfunction that extends beyond acute mood episodes. It is not known whether these dissimilar outcomes of bipolar disorder are driven by different polygenic profiles. Here, polygenic scores (PGSs) for major psychiatric disorders and educational attainment were assessed for associations with occupational functioning and psychiatric hospital admissions in bipolar disorder. Methods: A total of 4,782 patients with bipolar disorder and 2,963 control subjects were genotyped and linked to Swedish national registers. Longitudinal measures from at least 10 years of registry data were used to derive percentage of years without employment, percentage of years with long-term sick leave, and mean number of psychiatric hospital admissions per year. Ordinal regression was used to test associations between outcomes and PGSs for bipolar disorder, schizophrenia, major depressive disorder, attention deficit hyperactivity disorder (ADHD), and educational attainment. Replication analyses of hospital admissions were conducted with data from the Bipolar Disorder Research Network cohort (N=4,219). Results: Long-term sick leave and unemployment in bipolar disorder were significantly associated with PGSs for schizophrenia, ADHD, major depressive disorder, and educational attainment, but not with the PGS for bipolar disorder. By contrast, the number of hospital admissions per year was associated with higher PGSs for bipolar disorder and schizophrenia, but not with the other PGSs. Conclusions: Bipolar disorder severity (indexed by hospital admissions) was associated with a different polygenic profile than long-term occupational dysfunction. These findings have clinical implications, suggesting that mitigating occupational dysfunction requires interventions other than those deployed to prevent mood episodes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information:	The title of this article was changed during the publishing process; the original title was: 'Not all bipolar disorder outcomes are created equal: occupational dysfunction and hospital admissions associate with different polygenic profiles'
Publisher:	Psychiatry Online
ISSN:	0002-953X
Date of First Compliant Deposit:	4 December 2023
Date of Acceptance:	14 September 2023
Last Modified:	05 Nov 2024 18:16
URI:	https://orca.cardiff.ac.uk/id/eprint/164508

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