A brief history of metal recruitment in protozoan predation

Yu, Yanshuang, Li, Yuan-Ping, Ren, Kexin, Hao, Xiuli, Chi Fru, Ernest ORCID: https://orcid.org/0000-0003-2673-0565, Rønn, Regin, Rivera, Windell L., Becker, Karsten, Feng, Renwei, Yang, Jun and Rensing, Christopher 2024. A brief history of metal recruitment in protozoan predation. Trends in Microbiology 32 (5) , pp. 465-476. 10.1016/j.tim.2023.11.008

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Abstract

Metals and metalloids are used as weapons for predatory feeding by unicellular eukaryotes on prokaryotes. This review emphasizes the role of metal(loid) bioavailability over the course of Earth’s history, coupled with eukaryogenesis and the evolution of the mitochondrion to trace the emergence and use of the metal(loid) prey-killing phagosome as a feeding strategy. Members of the genera Acanthamoeba and Dictyostelium use metals such as zinc (Zn) and copper (Cu), and possibly metalloids, to kill their bacterial prey after phagocytosis. We provide a potential timeline on when these capacities first evolved and how they correlate with perceived changes in metal(loid) bioavailability through Earth’s history. The origin of phagotrophic eukaryotes must have postdated the Great Oxidation Event (GOE) in agreement with redox-dependent modification of metal(loid) bioavailability for phagotrophic poisoning. However, this predatory mechanism is predicted to have evolved much later – closer to the origin of the multicellular metazoans and the evolutionary development of the immune systems.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Earth and Environmental Sciences
Publisher:	Cell Press
ISSN:	0966-842X
Date of First Compliant Deposit:	5 December 2023
Date of Acceptance:	21 November 2023
Last Modified:	15 Dec 2024 02:45
URI:	https://orca.cardiff.ac.uk/id/eprint/164522

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