ROS mediated pro-apoptotic effects of Tinospora cordifolia on breast cancer cells

Ansari, Jamal Akhtar, Rastogi, Namrata, Ahmad, Mohammad Kaleem, Mahdi, Abbas Ali, Khan, Abdul Rahman, Thakur, Ravi, Srivastava, Vikas Kumar, Mishra, Durga Prasad, Fatima, Nishat, Khan, Homa Jilani and Waseem, Mohammad 2017. ROS mediated pro-apoptotic effects of Tinospora cordifolia on breast cancer cells. Frontiers in Bioscience-Elite 9 (1) , 89–101. 10.2741/E788

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Abstract

The inevitable development of chemoresistance and unmanageable side effects are the major therapeutic challenges in management of breast cancer imposing an urgent need for identification of novel therapeutic agents. In the present investigation, we report anti-proliferative activity of chloroform fraction of Tinospora cordifolia (TcCF), an Ayurvedic medicinal plant, on breast cancer cells. We found that TcCF inhibited growth of breast cancer cells, MDA-MB-231 and MCF-7. More interestingly, we observed TcCF treatment increased intra-cellular ROS levels, altered expression of pro and anti-apoptotic genes, decreased colony formation ability and induced apoptosis in breast cancer cells. We also found that inhibition of ROS abrogated TcCF induced apoptosis in breast cancer cells, emphasizing the role ROS in TcCF induced breast cancer cell death. Furthermore, we identified the presence of pharmacologically active compounds like rutin and quercetin which account for the anti-cancer property of TcCF against breast cancer cells. These data show TcCF is a promising anti-cancer agent against breast cancer cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	IMR Press
ISSN:	1945-0494
Last Modified:	19 Dec 2023 17:00
URI:	https://orca.cardiff.ac.uk/id/eprint/164612

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