Analysis of NAPA gene expression in brain structures of Wistar Rats during the formation of long-term spatial memory and physical activity under stress situation

Gruden, M. A., Ratmirov, A. M., Storozheva, Z. I. and Sewell, R. D. E. 2023. Analysis of NAPA gene expression in brain structures of Wistar Rats during the formation of long-term spatial memory and physical activity under stress situation. Bulletin of Experimental Biology and Medicine 175 (6) , pp. 810-813. 10.1007/s10517-023-05952-6

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Abstract

In the cerebellum, hippocampus, and prefrontal cortex of mature male Wistar rats with trained spatial navigational skill in the Morris water maze, the transcriptional activity the NAPA gene that regulates the transport and secretion of synaptic vesicles, release of neurotransmitters, and protein degradation was determined by real-time PCR. Animals subjected to forced swimming in a time-matched regime (active control) and naïve rats were used as the comparison groups. Suppression of NAPA gene activity was found in the hippocampus and cerebellum of the active control group, while navigation skill training led to a significant increase in gene expression in all brain structures under study. The findings suggest the existence of specific mechanisms regulating NAPA gene activity during the formation of spatial memory and adaptive behavior under stress conditions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Springer
ISSN:	0007-4888
Date of First Compliant Deposit:	18 December 2023
Date of Acceptance:	3 April 2023
Last Modified:	18 Nov 2024 02:45
URI:	https://orca.cardiff.ac.uk/id/eprint/164937

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