Cellular impacts of striatins and the STRIPAK complex and their roles in the development and metastasis in clinical cancers

Li, Amber Xinyu, Martin, Tracey A. ORCID: https://orcid.org/0000-0003-2690-4908, Lane, Jane ORCID: https://orcid.org/0000-0002-1926-4909 and Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111 2024. Cellular impacts of striatins and the STRIPAK complex and their roles in the development and metastasis in clinical cancers. Cancers 16 (1) , 76. 10.3390/cancers16010076

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Abstract

The STRIPAK (striatin-interacting phosphatase and kinase) complex and its central components, striatins (STRNs), have attracted significant interest with regard to the pathological development of diseases over the last decade, particular in the area of cancer research. Beyond their roles in regulating several oncogenic signalling cascades, the clinical relevance of the STRIPAK constituents has intensified research attention towards this supramolecular assembly. However, the complex nature of the complex poses research challenges, and our current understanding provides only a partial view of its functions. As a complex of phosphatases and kinases, its diverse signalling partners further complicate the precise determination of its roles within cancer development. Hence, further research is necessary to unveil and establish its significance as an emerging biomarker. This review consolidates the existing cellular and biological knowledge of STRNs and the STRIPAK members, while also highlighting their demonstrated clinical significance across various cancer types. The current research challenges and future perspectives are also discussed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	MDPI
ISSN:	2072-6694
Funders:	NA
Date of First Compliant Deposit:	22 December 2023
Date of Acceptance:	20 December 2023
Last Modified:	12 Jan 2024 10:45
URI:	https://orca.cardiff.ac.uk/id/eprint/165043

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