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Ring-closing metathesis (RCM) based synthesis of the macrolactone core of amphidinolactone A

Mohapatra, Debendra K., Pattanayak, Manas R., Das, Pragna P., Pradhan, Tapas R. ORCID: https://orcid.org/0000-0003-1480-7799 and Yadav, J. S. 2011. Ring-closing metathesis (RCM) based synthesis of the macrolactone core of amphidinolactone A. Organic and Biomolecular Chemistry 9 (16) , pp. 5630-5632. 10.1039/c1ob05335c

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Abstract

A convergent synthesis of the macrolactone core of amphidinolactone A has been achieved, in a 10 step linear sequence with 32% overall yield, through a ring-closing metathesis reaction as the macrolactonization step. The RCM precursor was obtained by the union of acid and alcohol fragments derived from (R)-epichlorohydrin and (R)-2,3-O-isopropylidene glyceraldehyde, respectively.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1477-0520
Date of Acceptance: 11 May 2011
Last Modified: 16 May 2024 01:40
URI: https://orca.cardiff.ac.uk/id/eprint/165587

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