Unexpected products of the reaction of cyanoacetylhydrazones of aryl/heteryl ketones with hydrazine: a new route to aryl/heteryl hydrazones, x-ray structure, and in vitro anti-proliferative activity against nci 60-cell line panel

Mohamed-Ezzat, Reham A., Kariuki, Benson M. ORCID: https://orcid.org/0000-0002-8658-3897 and Elgemeie, Galal H. 2023. Unexpected products of the reaction of cyanoacetylhydrazones of aryl/heteryl ketones with hydrazine: a new route to aryl/heteryl hydrazones, x-ray structure, and in vitro anti-proliferative activity against nci 60-cell line panel. Egyptian Journal of Chemistry 66 (13) , pp. 225-239. 10.21608/ejchem.2023.197330.7682

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Abstract

A new unexpected synthetic non-catalytic method for the synthesis of novel heteryl hydrazones for base-modification of nucleoside analogs has been developed. Characterizations of the products have been performed using NMR spectroscopy and single crystal x-ray diffraction analysis. Further in vitro anti-proliferative potency of the compounds against NCI 60 cell lines has been estimated. The results indicate anti-cancer activity by the compounds against several of the cancer cell lines.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
ISSN:	2357-0245
Date of First Compliant Deposit:	13 February 2024
Date of Acceptance:	24 April 2023
Last Modified:	10 Nov 2024 15:00
URI:	https://orca.cardiff.ac.uk/id/eprint/166283

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