The Wnt co-receptor PTK7/Otk and Its Homolog Otk-2 in neurogenesis and patterning

Tan, Qian Hui, Otgonbaatar, Agimaa, Kaur, Prameet, Ga, Angelica Faye, Harmston, Nathan P. and Tolwinski, Nicholas S. 2024. The Wnt co-receptor PTK7/Otk and Its Homolog Otk-2 in neurogenesis and patterning. Cells 13 (5) , 365. 10.3390/cells13050365

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Abstract

Wnt signaling is a highly conserved metazoan pathway that plays a crucial role in cell fate determination and morphogenesis during development. Wnt ligands can induce disparate cellular responses. The exact mechanism behind these different outcomes is not fully understood but may be due to interactions with different receptors on the cell membrane. PTK7/Otk is a transmembrane receptor that is implicated in various developmental and physiological processes including cell polarity, cell migration, and invasion. Here, we examine two roles of Otk-1 and Otk-2 in patterning and neurogenesis. We find that Otk-1 is a positive regulator of signaling and Otk-2 functions as its inhibitor. We propose that PTK7/Otk functions in signaling, cell migration, and polarity contributing to the diversity of cellular responses seen in Wnt-mediated processes.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences
Additional Information:	License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	MDPI
Date of First Compliant Deposit:	11 March 2024
Date of Acceptance:	16 February 2024
Last Modified:	11 Mar 2024 12:00
URI:	https://orca.cardiff.ac.uk/id/eprint/167087

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