Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria

Portal, E. A. R., Sands, K., Farley, C., Boostrom, I., Jones, E., Barrell, M., Carvalho, M. J., Milton, R., Iregbu, K., Modibbo, F., Uwaezuoke, S., Akpulu, C., Audu, L., Edwin, C., Yusuf, A. H., Adeleye, A., Mukkadas, A. S., Maduekwe, D., Gambo, S., Sani, J., Walsh, T. R. ORCID: https://orcid.org/0000-0003-4315-4096 and Spiller, O. B. ORCID: https://orcid.org/0000-0002-9117-6911 2024. Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria. Nature Communications 15 (1) , 2302. 10.1038/s41467-024-45673-6

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Abstract

A mobile colistin resistance gene mcr was first reported in 2016 in China and has since been found with increasing prevalence across South-East Asia. Here we survey the presence of mcr genes in 4907 rectal swabs from mothers and neonates from three hospital sites across Nigeria; a country with limited availability or history of colistin use clinically. Forty mother and seven neonatal swabs carried mcr genes in a range of bacterial species: 46 Enterobacter spp. and single isolates of; Shigella, E. coli and Klebsiella quasipneumoniae. Ninety percent of the genes were mcr-10 (n = 45) we also found mcr-1 (n = 3) and mcr-9 (n = 1). While the prevalence during this collection (2015-2016) was low, the widespread diversity of mcr-gene type and range of bacterial species in this sentinel population sampling is concerning. It suggests that agricultural colistin use was likely encouraging sustainment of mcr-positive isolates in the community and implementation of medical colistin use will rapidly select and expand resistant isolates.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Advanced Research Computing @ Cardiff (ARCCA) Medicine
Publisher:	Nature Research
ISSN:	2041-1723
Funders:	Bill & Melinda Gates Foundation
Date of First Compliant Deposit:	14 March 2024
Date of Acceptance:	30 January 2024
Last Modified:	12 Jun 2024 12:29
URI:	https://orca.cardiff.ac.uk/id/eprint/167269

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